Psidium guajava Linn (Myrtaceae) has been used as traditional medicine. The aim of the present research work was to investigate the gel formulation containing hydroalcoholic and methanolic extract of Psidium guajava leaves. Quercetin was taken as marker and it shows good in-vitro drug release from the results it was concluded that psidium guajava leaves extract when formulated in gel show significant drug release and hydoalcoholic extract gel show more drug release as compared with methanolic extract gel by using design expert approach.
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